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Additionally, when pristine Raw264.7 cells were treated with varying concentrations (0, 3, 6, 12, 25, 50, 75, 100, and 150 g/mL) of PDA and PDA@Pt, the PDA alone did not exhibit a significant decline in cell viability, while the PDA@Pt group showed a minor reduction at high concentrations, suggesting that the nanodrug is virtually non-toxic to normal Raw264.7 cells (Fig

However, this increase in metabolic activity is also associated with elevated ROS, which are known modulators of the functions of immune cells 32,41,43,44,103

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