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Anthony Didato, DMD Balanced Aesthetics + Wellness 90% of Serotonin Produced in the Gut Approximately 90% of the body's serotonin the neurotransmitter most associated with mood regulation is produced by enterochromaffin cells Cell (Yano et al., 2015) Gut-Brain Axis Bidirectional Communication The gut-brain axis describes bidirectional signaling between the enteric nervous system and central nervous system via the vagus nerve, immune Annals of Gastroenterology Leaky Gut (Intestinal Permeability) and Systemic Inflammation Increased intestinal permeability allows endotoxins (LPS) to enter the bloodstream, triggering systemic inflammatory cascades linked to anxiety, depression, brain fog, Frontiers in Immunology Overnight Fasting Improves Microbial Balance A 12-14 hour overnight fast improves microbial balance and insulin sensitivity

Endocrinology 151 , 143152 (2010)

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doi:10.1016/j.tibs.2013.09.001 Study: Mitochondrial dysfunction linked to aging can be mitigated by antioxidant support

These signals included dizziness (ROR, 1.30, 95% CI 1.271.33), tremor (1.37, 1.321.42), dysgeusia (1.72, 1.641.81), lethargy (1.24, 1.151.33), taste disorder (2.55, 2.332.80), presyncope (1.39, 1.251.54), parosmia (2.39, 2.072.75), allodynia (25.55, 21.7130.08), hypoglycemic unconsciousness (8.11, 6.949.46), brain fog (1.78, 1.512.10), hyperesthesia (1.40, 1.181.66), diabetic neuropathy (1.95, 1.612.36), hypoglycemic seizure (3.29, 2.324.66), ophthalmic migraine (3.14, 1.885.27), Wernickes encephalopathy (2.37, 1.394.04), diabetic hyperglycemic coma (3.07, 1.685.62), hyperglycemic unconsciousness (7.94, 4.2714.77), vagus nerve disorder (3.75, 1.927.32), and hyperglycemic seizure (5.85, 1.8118.90) (Fig