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10.3 Gene therapy In 1972, gene therapy was first proposed as a way to replacing bad DNA with good DNA (Friedmann and Roblin, 1972)

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Pharmaceuticals 17 (1), 54

We then conducted co-immunoprecipitation experiments from lysates of cells co-expressing TMEM55B-eGFP with individual HA-tagged TBC1D9B-domains (C-terminus (aa 8101250), N-terminus (aa 1450), TBC-domain (aa 450810), TBC + EF-hand domain (aa 450950), TBC + GRAM domain (aa 301810)) (Fig

In vivo studies Experimental work Animals were maintained under specific-pathogen-free conditions and in compliance with the Northern Ireland Department of Health (under PPL 2874 and 2960) regulations with approval from the QUB Animal Welfare and Ethical Review Body