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The optimal administration route in humans has not been definitively established through clinical trials

While this represents a reasonable duration for clinical trials, it provides limited information about safety with years-long continuous use

Neither source is perfect alone

For instance, treatments with apple polysaccharides, flos lanicera, and Bofutsushosanan herbal remedy from Japanhave been successful in promoting the growth of beneficial bacteria like Lactobacillus and Bacteroidetes , improving intestinal barrier integrity, and decreasing pro-inflammatory cytokines such as TNF- and IL-6 [117,118,119]

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