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4.1.3 Clinical application of glutathione As the major intracellular antioxidant, glutathione effciently alleviates oxidative pressure levels in periodontal tissues (Ribas et al., 2014), (Valenti et al., 2023)

A blood test is the most reliable way to confirm whether B12 deficiency is a contributing factor

Dysregulation of the kynurenine pathway, as evidenced by low kynurenine levels has been linked to cognitive impairments such as brain fog and memory issues, which are commonly reported in both ME/CFS and FM (Groven et al., 2021

This cycle of ROS generation and lipid peroxidation perpetuates oxidative injury, worsening inflammation, vascular permeability, and respiratory dysfunction in ARDS patients (91)

Acknowledgements The authors thank Emelia Tremblay and Mazie Gordon at the University of Maine, for their help with microbial lab work, Benjamin and Timothy Hunt at the University of Maine for their work reviewing literature on GR converting genes, and Scott Leonard at Oregon State University for analyzing urine samples for nitrile content