It can be very difficult to watch someone you love deal with symptoms of dementia, which often include memory loss and trouble with language, along with personality changes, delusions, agitation and less ability to solve problems or control their emotions
De Jaco A, Bernardini L, Rosati J, Tata AM (2017) Alpha-7 nicotinic receptors in nervous system disorders: from function to therapeutic perspectives
2017;5:Article 162
It triggers the nonclassical nuclear factor kappa-B (NF-B) signaling pathway, produces cytokines and chemokines, promotes inflammation, and damages cellular function ( 1177 in endothelial cells (ECs) to produce nitric oxide (NO) to maintain normal endothelial function ( Intracellular hyperglycemia can increase production of advanced glycation end products (AGEs), promoting the interaction of AGEs and the advanced glycosylation end product-specific receptor (AGER, also known as RAGE)
Comparison of synthetic membranes to heat-separated human epidermis in skin permeation studies in vitro