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Probiotic intake does not directly alter thyroid function compensation, but it helps prevent serum hormone fluctuations and maintains thyroid hormone homeostasis

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As shown in Figure 3A, reduced expression levels of IL-6 and 8 and MMP3, 12 and 13 were observed in the FOXO4-DRI treated group, which however were concomitantly accompanied with reduced expression of SOX9 and COL2 , as well as increased expression of CDKN2A, CDKN1A , and TP53 (encoding p53)

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This process can involve gut microbiota metabolites crossing the blood-brain barrier, modulating the microbiota-gut-brain axis, and regulating microglial activity and cytokine release