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The oral cavity contains salivary amylase, peptidases, and a pH that fluctuates between 6.2 and 7.4 depending on recent food intake

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The lack of IGF-1R on the membrane is a reasonable predictor of poor response to IGF-1R mAbs, but small molecule TKIs should still be effective

Bromodomain and extraterminal (BET) protein inhibition sensitize BRAFV600E colorectal cancer to standard targeted therapies

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