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Introduction Under normal physiological conditions, cells can generate a massive amount of reactive oxygen species (ROS) during metabolism in the presence of oxygen

Once in the extracellular space, GSH can be degraded by the membrane-bound ectoenzyme gamma-glutamyltransferase (GGT, also known as -GT), which cleaves the -glutamyl bond, releasing cysteinyl-glycine (Cys-Gly) 26,27

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The universal role of NADPH as the primary electron donor for most biological reductions, including for supporting disulfide reduction systems, made the uncovering of an apparently NADPH-independent disulfide reduction system in mouse liver surprising