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Mutat Res (2012) 736:6474.10.1016/j.mrfmmm.2011.06.004 23 StepanovIKnezevichAZhangLWatsonCHatsukamiDKHechtSS

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(1) the metabolism of estrogen to genotoxic, mutagenic carcinogens, (2) the stimulation of tissue growth, and (3) the repression of phase II detoxification enzymes that metabolize ROS leading to increased oxidative DNA damage