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ROS Overproduction: The Initiating Driver Hyperglycaemia activates multiple simultaneous ROS sources, including mitochondrial uncoupling, NADPH oxidase isoforms NOX2 and NOX4, and xanthine oxidase upregulation

SCFAs upregulate the expression of tight junction proteins such as ZO-1 and claudin-1 and mucin (MUC2), improve intestinal epithelial barrier function and reduce intestinal permeability 161

Design, optimization, and evaluation of a pH-sensitive hydrogel system for colon-targeted mesalamine delivery

Silymarin is found in high concentrations in milk thistle extract and is well known for its antioxidant properties

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