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NSAIDs are a common cause of gastric ulcers and intestinal lesions due to their inhibition of prostaglandin synthesis, which is crucial for mucosal defense

To address this, new potential markers are continuously being developed and qualified, resulting in a substantial increase of biomarker research (Xie et al

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NAD+ is a systemic coenzyme involved in cellular energy, DNA repair, and longevity, usually taken orally or via infusion

Also, salvianolic acid B pretreatment induces Nrf2 and phase II enzymes by activating phosphoinositide 3-kinase (PI3K) and protein kinase C (PKC) pathways, thereby preventing acetaminophen-induced hepatotoxicity in mice (Lin et al., 2015)