130 Leptin selectively increases the expression of the astrocytic 5-HT 2B receptor by activating the JAK2/STAT3 pathway, and fluoxetine in turn stimulates the 5-HT 2B receptor and increases the secretion of brain-derived neurotrophic factor (BDNF) from astrocytes in vivo, thus ameliorating depressive-like behaviors
If systemic iron overload is corrected, over time the hemosiderin is slowly resorbed by the macrophages
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It promotes angiogenesis (the formation of new blood vessels), enhances tissue repair, and exhibits powerful anti-inflammatory properties
Pena DA, Gasser B, Zanghellini J, Steiger MG, Mattanovich D (2018) Metabolic engineering of Pichia pastoris