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In Groups 1 and 2, healthy volunteers achieved steady-state levels within 12-16 hours without a loading dose, showing higher CD bioavailability than oral administration, with an optimal 20:1 dosing ratio

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(The cost of B12 is pennies but the time for nurses to give the injection appears to be the saving here.) Some practices are enclosing diet sheets for patients to learn how to make sure they are eating foods containing B12