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Organic Acid Testing includes indirect markers such as pyroglutamic acid that may reflect increased oxidative stress or reduced glutathione recycling capacity

A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression

LDHB KD significantly downregulated GSH synthesis genes, such as glutamate-cysteine ligase (GCL) catalytic and modifier subunits (GCLC and GCLM), GSH synthetase (GSS), and GSH reductase (GSR), as well as the GSH gene signature ( Figure 1f

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