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Immunofluorescence microscopy Cells were grown on glass coverslips and fixed with 4% (w/v) paraformaldehyde (PFA) in PBS for 20 min at room temperature and permeabilized with 0.2% (w/v) saponin in PBS for 5 min at room temperature

Authors: Margret I

As novel transdermal platforms, these systems enable multi-target gout therapy by combining alpha-phellandrene with colchicine ( 4.2.4 Self-emulsifying drug delivery systems Self-emulsifying drug delivery systems (SEDDSs) represent lipid-based formulations that spontaneously form emulsions or microemulsions in gastrointestinal environments, including self-nanoemulsifying DDSs and self-microemulsifying DDSs (SMEDDSs), significantly enhancing the oral bioavailability of lipophilic drugs ( ex vivo degradation ( In addition, complementary mechanisms provide support for the efficacy of SEDDSs/SMEDDSs in hyperuricemia, as detailed below

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The G protein-coupled receptors that the released agonists activate include the thrombin receptor (F2R), thromboxane A2 receptor (TBXA2R), and adenosine diphosphate (ADP) receptors (P2RY1 and P2RY12)