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Insufficient maternal nutrition, especially during critical periods of embryonic and fetal development, manifests as an overall elevation of ovarian OS, which, along with impaired mitochondrial antioxidant defenses, may be responsible for these significantly decreased follicle numbers and resultant growth impediment of offspring [275]
Most of the existing studies have focused on the regulation of core molecules of the AMPK pathway (such as ACC, mTOR, and SEBP-1C), but its interaction with other metabolic pathways (such as PI3K/Akt, FGF21, and the gut microbiota-liver axis) has not been fully clarified, which limits the comprehensive understanding of the complex regulatory network in NAFLD
An omics perspective on drug target discovery platforms
10.1016/j.phrs.2023.106733 180 YuL.LiuM.WangZ.LiuT.LiuS.WangB.et al (2021)
To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
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