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Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs

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The S-Traps containing trapped protein were washed twice by centrifuging through 90% methanol and 100 mM TEAB

ACSL4 catalyzes the binding of long-chain PUFAs, such as arachidonic acid (AA) and adrenic acid (AdA), to coenzyme A (CoA) [33], after which these products are re-esterified by lysophosphatidylcholine acyltransferase 3 (LPCAT3) to form phospholipids [34]