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People with untreated hypothyroidism should delay sermorelin until their thyroid condition is managed, because low thyroid hormone levels can make sermorelin ineffective (thyroid hormone is important for growth hormone action)

Drug Interactions: A Largely Unmapped Territory BPC-157 has documented pharmacodynamic interactions with at least the following drug classes in animal models: NSAIDs (it modulates COX-mediated prostaglandin pathways), corticosteroids (it has counter-regulatory effects on glucocorticoid-induced tissue atrophy), SSRIs and SNRIs (via serotonin system crosstalk), and anticoagulants (via platelet and NO pathway effects)