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May 24 2024;doi:10.1056/NEJMoa2403347

These changes were accompanied by marked downregulation of junctional proteins zonula occludens-1 (ZO-1), Ecadherin, and occludin ( in vitro findings link ferroptotic signaling to impaired intercellular adhesion and increased epithelial permeability, suggesting a plausible mechanism for enhanced bacterial translocation into deeper periodontal tissues in vivo

Protocol overview: BPC-157 administered via subcutaneous injection, locally near the affected joint Standard dosing range: 200500 mcg per injection session Treatment duration: 48 weeks of active treatment Follow-up assessments: 6 months and 12 months post-treatment Patients were evaluated using validated pain scales (VAS and KOOS scores) and functional mobility assessments at each follow-up point

BPC-157: Over 100 preclinical studies, 25-plus years of research, multiple independent research groups, limited human clinical data, extensive physician-supervised clinical experience

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