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(2016) observed cirrhosis patients exhibiting over twice the muscle loss rate compared to healthy individuals, with a notable increase in mortality when muscle loss exceeded 3%

the highest expression levels are in the lung, spleen, kidney, liver, and myeloid cell lineages, particularly neutrophils, mast cells, monocytes, macrophages, and their precursors (32)

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Research has explored their combined use in facilitating recovery following soft tissue trauma, surgery, or overuse injury, although further data is needed

doi: 10.1124/jpet.114.215145 54 WangCSongYWangXMaoRSongL