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For instance, an IgG-Fc conjugated ancestral Wuhan-Hu-1 RBD sequence adjuvanted with a novel STING agonist CF501 induced potent nAb activity against SARS-CoV-2 Omicron and XBB variants in macaques, mice, and rabbits [159, 160] (Table 2)

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Idiopathic neuropathy When the cause of neuropathy is unknown, which affects roughly 25% of patients, a broad-spectrum approach targeting multiple mechanisms makes the most sense

In recent GLP-1RA trials focusing on patients with obesity, favourable effect on worsening heart failure in HFpEF patients was indicated to be modulated by baseline BMI [32], although the underlying mechanisms that explain the cardiovascular and renal benefits may not necessarily be due to weight loss alone

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