J King Saud Univ Sci 26(4):285289
Chronically high homocysteine can lead to issues with your heart, brain, and immune system
In the periphery, as an instant progression from the central disturbance, a multiorgan failure syndrome appeared, comparable to the deadly syndromes induced by the peripheral vessels occlusion, the suprahepatic occlusion of the inferior caval vein (BuddChiari syndrome) or Pringle maneuver ischemia, reperfusion (i.e., heart, lung, liver, kidney, gastrointestinal lesions and thrombosis progression) [26,27]
Atherosclerosis, in turn, is a chronic inflammatory disease, fueled by oxidized lipids and influenced by various immune and nonimmune cells including vascular endothelial and smooth muscle cells, monocytes and macrophages, T cells, B cells, and red blood cells
Because of this defect, the body cant accumulate sufficient carnitine inside the cells, leading to carnitine depletion