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HGF II stabilizes c-MET II-HGF I interaction by forming a tripartite interface In the majority of the particles, the second HGF (i.e., HGF II) adopts a flexible conformation with only its SPH domain, which contacts c-MET II-SEMA, being well resolved in the cryo-EM map

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Modern medicine uses synthesized versions of these molecules to treat metabolic diseases, genetic disorders, and bacterial infections