Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer
Macronutrient balance, reproductive function, and lifespan in aging mice
This susceptibility was elegantly illustrated in the LEGSKO mouse model, where de novo GSH synthesis in the lens is abolished via knockout of -glutamyl-cysteine ligase [139,140,141]
Moreover, a recent randomized crossover study in healthy women demonstrated that prolonged mild sleep restriction markedly increased endothelial oxidative stress without activating compensatory antioxidant responses, due to reduced expression of DCUN1D3 gene, a regulator of the Nrf2-mediated antioxidant pathway, thereby suggesting a mechanistic link between insufficient sleep and vascular oxidative injury 78
H 2 O 2 scavenging ratio (%) = (A A n )/(A b A n ) 100%, where A represents the absorbance value for the sample group, A b represents the absorbance value for the BC group and A n is the absorbance value for the NC group
