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Abruptly stopping tirzepatide after months of use leads to rapid appetite return and weight regain in most people

Fatigue (20%) Fatigue or feeling more tired than usual was also a reported side effect

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It does not rebuild tissue on its own

Those characterized by inhibitory (GABAergic) inputs may function as an incoherent FFL, acting to pulse activity, as illustrated by the transient inhibitory effects of the sst1 agonist at the synaptic GABAergic level (see Fig