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Dendrite length was determined using the National Institutes of Health's Image J 1.41o program (NIH, Bethesda, MD) and the neurite tracing program Neuron J (Meijering et al., 2004) Spines were manually counted

doi: 10.3389/fphar.2014.00196 Received 05 July 2014 Accepted 06 August 2014 Published 26 August 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Anastassios Papageorgiou, University of Turku, Finland

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However, the underlying causal mechanisms remain under active investigation