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Recent Adv Tob Sci

1964), combined with observational studies showing the association between emphysema and deficiency of 1-antitrypsin (AAT) (Laurell and Eriksson 1963), led naturally to the hypothesis that the pathogenesis of emphysema was based on a functional proteolytic imbalance within the inflammatory response induced by tobacco smoke(Gadek et al

The cigarette as we know it is a very recent and considerably less poetic descendant of that tradition

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2015: the list of prohibited additives was widened and the definition of covered products broadened