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Previously reported changes in the abundance of this family Prevotellaceae in advanced PD seem to have been expanded upon by Bedarf and associates, who have shown a dramatic decrease in the numbers of Prevotella copri in patients with early-stage PD ( Prevotella produce SCFAs like butyrate, their decrease may affect intestinal barrier function and immune health and thus be involved in the pathogenesis of PD (Hey et al., 2023)

Milewski , Dziunycz P, Barcz E, Radomski D, Roszkowski PI, Korczak-Kowalska G, et al

Hum Reprod 34:25132522

For a long time, cell death was considered uncontrolled

Remarkably, more patients treated with MTX/HCQ were able to withdraw glucocorticoid exposure than those treated with MTX/LEF (107)