Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer
223 Under hypoxic pressure, autophagy orchestrates selective degradation of cellular components, including mitochondria (mitophagy), ER (ER-phagy), lipid droplets (lipophagy), ribosomes (ribophagy), nuclei (nucleophagy), and peroxisomes (pexophagy), 224,225,226,227 thereby sustaining tumor metabolism and viability
Wang C, Zhao M, Liu YR, Luan X, Guan YY, Lu Q, et al
With the exception of acetylation, methylation and fatty acid conjugation, the strategy of phase II biotransformation is to convert a xenobiotic to a more hydrophilic form via the attachment of a chemical moiety which is ionizable at physiological pH
Zhou R, Xu Q, Zheng P, Yan L, Zheng J, Dai G