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Treatment of adipocytes isolated from HSL-null mice with the beta-adrenergic agonist isoproterenol causes enhanced lipolysis, albeit at a blunted level compared with adipocytes from wild-type animals (91)

Studied in preclinical beta-3 adrenergic receptor-mediated lipolysis models and more recent chondroprotection research

Adipex and Suprenza (phentermine) Qsymia (phentermine-topiramate) Contrave (naltrexone-bupropion) Xenical and Alli (orlistat) Imcivree (setmalanotide) Plenity (carboxymethylcellulose hydrogel) Several additional agents are used off-label for weight loss at acceptable risk when prescribed thoughtfully and documented as off-label

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The researchers reported that lowering NNMT expression changed metabolic pathway activity and energy use