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HMGB1 depletion results in several alterations: (1) inhibition of lipid peroxidation, (2) A decrease in the cellular iron level, and (3) a reduction in the anticancer activity of erastin, both in vitro and in vivo via a RAS-JNK/p38-dependent mechanism

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The low incidence of bleeding complications, even in adequately anticoagulated patients undergoing IVT, underscores the importance of tailored acute stroke management