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SLC7A11 mediated cystine uptake is crucial to main redox homeostasis and biomass incorporation in cells (2, 4)

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Access this article Similar content being viewed by others Abbreviations FOX: Forkhead box FOXO: Forkhead box O PI3K: Phosphatidylinositol-3-kinase JNK: c-Jun N-terminal kinase MLL: Mixed-lineage leukemia FHD: Forkhead winged-helix DNA-binding domain NLS: Nuclear localization sequence NES: Nuclear export sequence TAD: Transactivation domain CRM1: Chromosomal maintenance 1 TNF-: Tumor necrosis factor alpha MST1: Mammalian ste20-like kinase AMPK: AMP-activated protein kinase ERK: Extracellular signal-regulated kinase NLK: Nemo-like kinase CK1: Casein kinase 1 DYRK1A: Dual-specificity tyrosine-phosphorylated regulated kinase 1A CBP: CREB-binding protein SIRT1: Silent information regulator 1 HDAC: Histone deacetylase MDM2: Murine double minute 2 SKP2: S-phase kinase-associated protein 2 USP7: Ubiquitin-specific protease 7 TNPO1: Transportin 1 TCF: T cell factor NF-B: Nuclear factor B SOD2: Superoxide dismutase 2 ROS: Reactive oxidative species GADD45: Growth-arrest and DNA damage-response protein 45 Bcl-xl: B cell lymphoma extra-large Bcl-6: B-cell lymphoma 6 Bim: Bcl-2 interacting mediator Bax: Bcl-2 associated X protein SMC: Smooth muscle cell SRF: Serum response factor HIF1: Hypoxia-inducible factor 1 protein VEGF: Vascular endothelial growth factor MAFbx: Muscle atrophy F-box MuRF1: Muscle ring finger 1 TNF: Tumor necrosis factor WNK: With-no-lysine kinase AGE: Advanced glycation end product TNM: Tumor node metastasis References Huang H, Tindall DJ (2007) Dynamic FoxO transcription factors

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