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6.3 Cardiovascular diseases Cardiovascular diseases (CVDs) are also characterized by insulin resistance, a pro-oxidative and pro-inflammatory state, as well as a dysregulation of the expression of various factors responsible for the homeostasis of redox and inflammatory environment [62]

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So far, eight isoforms of Gpx have been identified in humans, which vary in cellular location and substrate specificity ( 2 O 2 and has been classically believed to be the major H 2 O 2 reducing enzyme

The results indicate that the proposed models are helpful in predicting the carcinogenicity of chemicals 41

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