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Alongside VEGF, HIF-1 also induces other angiogenic mediators such as angiopoietins, platelet-derived growth factor (PDGF), and stromal-derived factor-1 (SDF-1), which collectively orchestrate the complex remodeling of the tumor vasculature (166, 169)

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This may be due to women having higher levels of estrogen, body fat, and lower levels of body water than men

Product is generally good for up to 3 years for this date if stored properly