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Description

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These obese mice also showed activation of microglia and astrocytes and significant immunoreactivity of neuroinflammatory and apoptosis markers, such as TNF-, COX-2, and Caspase-3, in addition to lower expression of neurogenesis and synaptic plasticity markers, such as NeuN, KI-67, CREB-p, and BDNF

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Kartini D, Taher A, Panigoro SS, et al

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The pyruvate generated is transported into the mitochondria to enter the TCA cycle to generate citrate

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