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Don't mix with harsh actives

Our finding that SLC7A11 knockdown in p53 Null models sensitized cells to APR-246, while SLC7A11 overexpression in mut-p53 models generated drug resistance, indicates that the therapeutic activity of APR-246 is dependent not only upon mut-p53 status, but also on the basal level of SLC7A11 expression and intracellular GSH

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[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Wiwatchaitawee K, Ebeid K, Quarterman JC, Naguib Y, Ali MDY, Oliva C, Griguer C, Salem AK

3-D cell discs were formed by culturing vascular smooth muscle cells in collagen first and then 3-D discs with similar size were incubated in different media for 24 h