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Handb Exp Pharmacol 2014;220:67-100

The information provided herein is for informational and educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment

doi: 10.15414/jmbfs.2017/18.7.3.281-286 4

Naltrexone, used for addiction to opioids or alcohol, is an opioid receptor antagonist that has minimal effect on weight loss alone

The existing MetS-associated animal models induced by high-fat diets are mainly rodent models, including (diabetic ED rats, hyperlipidemic ED rats, etc.), which may only lead to obesity or insulin resistance, but lack key manifestations such as hypertension or inflammation