For the systemic injury and recovery uses that TB-500 is actually marketed for, the supporting data are animal models and in-vitro work on thymosin beta-4 and its actin-binding domain
The logic made sense: if the peptide promotes blood vessel formation and accelerates tissue repair in animal studies, perhaps it could help a chronically inflamed tendon finally heal
(2) When studied together in vitro, TB-500 and BPC-157 have been observed to overlap in some functional areas and complementary actions
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6.2.3 Demyelinating injury 6.2.3.1 Myelination disorder Human myelination begins in mid-gestation and peaks during the first few years after birth, continuing into adulthood (van der Westhuyzen et al., 1982)