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Our findings describe a role for mitochondrial plasticity as a mechanism for acute 5FU tolerance in CRC cells: mitochondrial changes acutely adopted by CRC cells in response to 5FU-based standard-of-care treatment result in increased mitochondrial biogenesis, which provides metabolic support for increased pyrimidine scavenging by UCK2 to resolve nucleotide stress
doi: 10.1016/j.cell.2018.02.048 66 DuJWangTLiYZhouYWangXYuXet al
A slow IV push, by contrast, does not add an ingredient to the bag, which is part of why it is the cleaner option when a protocol is already near that limit
A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine)
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