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Fat Loss: Users often experience a reduction in body fat percentage

"Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2.4 mg for weight management." Diabetes Care , 44(6), 1313-1321

For orforglipron, participants initiated on higher doses and those on rapid titration schemes appeared to have higher discontinuation rates, providing insights into the optimisation process for the phase 3 trials

Semaglutide has become very popular because clinical studies show it can lead to about 15% body weight loss on average