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This article mainly focuses on the research of amino acid metabolism in tumor-oriented diseases, and reviews the research and clinical research progress of metabolic diseases, cardiovascular diseases and immune-related diseases related to amino acid metabolism, in order to provide theoretical basis for targeted therapy of amino acid metabolism

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Glossary AC adenylyl cyclase ACC1 acetyl-CoA carboxylase 1 ACLY ATP-citrate lyase ADAM17 a disintegrin and metalloprotease 17 ALT alanine aminotransferase AMPK AMP-activated protein kinase APCs antigen-presenting cells AST aspartate aminotransferase ATGL Adipose triglyceride lipase ATP adenosine triphosphate BAFF B cell-activating factor BCR B cell receptor BMI body mass index Breg regulatory B cell -AR beta-adrenergic receptor CaMKK calcium/calmodulin-dependent protein kinase kinase CAR chimeric antigen receptor CCL C-C motif chemokine ligand CCL2 C-C motif chemokine ligand 2 CCl4 carbon tetrachloride CCR2 C-C motif chemokine receptor 2 CD cluster of differentiation CD1d non-classical MHC class I-like molecule cDC conventional dendritic cell cDC1 conventional type-1 dendritic cell cDC2 conventional type-2 dendritic cell CLS crown-like structure CXCL C-X-C motif chemokine ligand CXCR C-X-C motif chemokine receptor DAG diacylglycerol DAMPs damage-associated molecular patterns DC dendritic cell DGAT diacylglycerol acyltransferase DNA deoxyribonucleic acid dNKT diverse natural killer T cell DNL de novo lipogenesis ECM extracellular matrix ER endoplasmic reticulum EV extracellular vesicles FAP fibroblast activation protein FASN Fatty acid synthase FFA free fatty acid FOXO1 forkhead box protein O1 Foxp3 forkhead box protein 3 FXR farnesoid X receptor G3P glycerol-3-phosphate GCK glucokinase GLI2 GLI Family Zinc Finger 2 GLP-1 glucagon-like peptide-1 GLUT glucose transporter GM-CSF granulocyte-macrophage colony-stimulating factor GPX4 glutathione peroxidase 4 GSDMD gasdermin D HCC hepatocellular carcinoma HFD high-fat diet HSC hepatic stellate cell HSL hormone-sensitive lipase IFN- interferon gamma Ig immunoglobulin IHH Indian hedgehog IL interleukin ILC innate lymphoid cell INF- Interferon gamma iNKT invariant natural killer T cell IR insulin receptor JAK Janus kinase KCs Kupffer cells LAM lipid-associated macrophage LIGHT/TNFSF14 tumor necrosis factor superfamily 14 LPS lipopolysaccharide LSEC liver sinusoidal endothelial cell LTi lymphoid tissue inducer MAG monoacylglycerol MAIT mucosal-associated invariant T cell MASH metabolic dysfunction-associated steatohepatitis MASLD metabolic dysfunction-associated steatotic liver disease MCD methionine- and choline-deficient MD2 Myeloid Differentiation Factor-2 MDM monocyte-derived macrophage MGL monoacylglycerol lipase MHC major histocompatibility complex miR/miRNA microRNA MMP matrix metalloproteinase MR1 MHC class I-related protein 1 mTOR mammalian target of rapamycin MyD88 myeloid differentiation primary response protein 88 M macrophage NASH non-alcoholic steatohepatitis NET neutrophil extracellular traps NF-B nuclear factor kappa B NKG2D natural killer group 2 member D NKp46 natural killer cell p46-related protein NKT natural killer T cell NLR Neutrophil-to-Lymphocyte Ratio NLRP3 nucleotide-binding domain and leucine-rich repeat protein-3 OSE oxidation-specific epitopes PDGF platelet-derived growth factor PDGFR platelet-derived growth factor receptor PD-L1 programmed death ligand 1 PI3K phosphatidylinositol 3-kinase PKA protein kinase A PPAR peroxisome proliferator-activated receptor PRR pattern recognition receptor PUFA polyunsaturated fatty acid RAE1 retinoic acid early inducible 1 protein RNA ribonucleic acid ROS reactive oxygen species SAMs scar-associated macrophages SCD1 Stearoyl-CoA desaturase 1 SGLT-2i -glucose cotransporter 2 inhibitor SREBP-1c sterol regulatory element-binding transcription factor 1c STAT signal transducer and activator of transcription TAG triacylglycerol TAZ transcriptional co-activator with PDZ-binding motif TCR T cell receptor TGF- transforming growth factor beta Th T helper cell THR- thyroid hormone receptor- TLR Toll-like receptor TNF-R Tumor necrosis factor receptor TNF- tumor necrosis factor alpha TRAIL tumor necrosis factor-related apoptosis-inducing ligand TRAIL-R tumor necrosis factor-related apoptosis-inducing ligand receptor Treg regulatory T cell TREM2 triggering receptor expressed on myeloid cells 2 uPAR urokinase plasminogen activator receptor UPR unfolded protein response VEGF vascular endothelial growth factor VLDL very low-density lipoprotein XCR1 chemokine receptor expressed on type 1 conventional dendritic cells References 1 LudwigJViggianoTRMcGillDBOttBJ