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PMID: 30788239

2018;7(9):E258.doi:10.3390/jcm7090258 Cui D, Moldoveanu Z, Stephensen CB.High-level dietary vitamin A enhances T-helper type 2 cytokine production andsecretory immunoglobulin A response to influenza A virus infection in BALB/cmice

Discussion The efficacy and safety of therapeutic agents are significantly influenced by individual patient variations, disease complexity, and drug metabolism

This is a mechanistically appealing strategy with strong preclinical support

This is the application area with the deepest preclinical history, and it is also where oral administration has a particularly direct anatomical rationale - the compound passes through the GI tract it was originally studied in relation to