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In some embodiments, a formulation described herein further comprises from about 14 to about 17% of a gelling agent (e.g., poloxamer 407), and provides extended sustained release over a period of from about 1 week to about 3 weeks

4,5 Diabetic conditions are characterized by hyperglycemia, hyperlipidemia, and inflammation, which converge to impair pancreatic -cell function

As one of the most extensively studied cytoprotective peptides, it has a deep preclinical literature spanning tissue repair, gastrointestinal protection, angiogenesis, and the nitric oxide system

The Journal of Steroid Biochemistry and Molecular Biology

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