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Its watersoluble, 95 % purity formulation and short plasma halflife (78 minutes) allow rapid crossing of the bloodbrain barrier, where it enhances deltawave (slowwave) activity the deepest stage of restorative sleep DSIP is a nonapeptide (TrpAlaGlyGlyAspAlaSerGlyGlu) first isolated from rabbit brain and produced in the human hypothalamus

In contrast to the expression of OAT1/3 in renal tubules, human RBC uptake of IS occurs via the help of the OAT2 transporter

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Aoyama K (2021) Glutathione in the Brain