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Annu Rev Pharmacol Toxicol (2019) 59:55575

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The IV infusion is typically well tolerated when administered by trained professionals

Based on these findings, Eisai conducted a Phase 2/3 trial (NCT00444613) in Japan to evaluate the safety and efficacy of ultrahigh-dose methylcobalamin injections in 373 adults whose ALS symptoms began up to three years before enrollment