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Am J Med Genet A 161A (6): 1425-31, 2013

Subsequently, caspase-1 is drawn to the ASC assembly, where it oligomerizes along the ASC filaments

High-dose oral supplements (often 10002000 micrograms daily) or intramuscular injections (typically 1mg hydroxocobalamin) used to treat pernicious anaemia or deficiency states can temporarily elevate serum levels

The process of cellular senescence involves multiple factors, including DNA damage, telomere shortening, and epigenetic changes, which lead to cell cycle arrest and ultimately result in cellular senescence (Zhang et al., 2024)

In general, using these compounds is expected to be a new pathway to developing drugs for IS by suppressing ferroptosis