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Because it lacks long-term human clinical trials, the full long-term side effect profile is unknown

doi: 10.1186/1475-2840-9-31 46 TassoneEJSciacquaAAndreozziFPrestaIPerticoneMCarnevaleDet al

Direct supplementation risks disrupting the body's innate GH rhythm, potentially resulting in side effects like joint pain, muscle aches, or even more severe conditions like diabetes

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