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Metabolic decompensation: usually occurs in infants aged 3 to 24 months, manifested by hypoglycemic coma, feeding difficulties, irritability, lethargy, hepatomegaly, elevated liver enzymes, and elevated transaminases

These in turn connect to the muscles

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In vitro and in vivo studies have also demonstrated that resveratrol mediates the levels of TSH and iodide uptake in thyrocytes by decreasing NIS expression (184)

Further Nrf2 translocates into the nucleus, heterodimerizes with one of the small musculo-aponeurotic fibrosarcoma (sMaf) proteins, binds to the antioxidant responsive element (ARE) or electrophile responsive element (EpRE) and promotes the transcription of genes encoding defense proteins/enzymes (Yamamoto et al., 2018)