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Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as a pivotal treatment option for both conditions, demonstrating efficacy in blood glucose management, weight reduction, cardiovascular disease prevention, and kidney health improvement

337 Astrocytes affect synaptic transmission via glutamate uptake by the glutamate transporters GLAST and GLT1 and via regulation of synaptic function and plasticity mediated by calcium signalling

This calculus matters for conditions requiring strong systemic effects

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By comparison, people on cagrilintide alone achieved an average 8.1% loss, while Wegovy hit a 5.1% decrease